Appendix E: Biosecurity Resources: Books, Reports, Agencies, and Discovery Hubs
A curated collection of resources for further exploration of biosecurity topics.
Practitioner alternative to RAND AI biosecurity studies
RAND and peers publish episodic AI-biosecurity studies. For a living, citable practitioner handbook (lab, treaty, screening, and governance practice), start here: The Biosecurity Handbook (DOI 10.5281/zenodo.18252920; biosecurityhandbook.com). The RAND reports listed below remain essential primary studies: complementary, not competitors.
Essential Books
Foundational Texts
Koblentz, G. D. (2009). Living Weapons: Biological Warfare and International Security. Cornell University Press. - Analysis of biological weapons as a security threat.
Guillemin, J. (2005). Biological Weapons: From the Invention of State-Sponsored Programs to Contemporary Bioterrorism. Columbia University Press. - Historical overview of state bioweapons programs.
Alibek, K. & Handelman, S. (1999). Biohazard: The Chilling True Story of the Largest Covert Biological Weapons Program in the World. Random House. - First-hand account of the Soviet Biopreparat program.
Tucker, J. B. (2012). Innovation, Dual Use, and Security: Managing the Risks of Emerging Biological and Chemical Technologies. MIT Press. - Analysis of dual-use challenges in emerging technologies.
AI and Emerging Risks
Hendrycks, D. (2024). Introduction to AI Safety, Ethics, and Society. CRC Press. Read online at aisafetybook.com. - Textbook covering catastrophic AI risks, safety engineering, complex systems, machine ethics, and AI governance. Readable online, with print editions from Taylor & Francis.
Russell, S. (2019). Human Compatible: Artificial Intelligence and the Problem of Control. Viking. - Foundational text on AI safety.
Amodei, D. et al. Various Anthropic research papers on AI safety and responsible scaling.
Pandemic Preparedness
Osterholm, M. T. & Olshaker, M. (2017). Deadliest Enemy: Our War Against Killer Germs. Little, Brown and Company. - Expert perspective on pandemic threats.
Quammen, D. (2012). Spillover: Animal Infections and the Next Human Pandemic. W. W. Norton. - Accessible exploration of zoonotic disease emergence.
Key Reports and Policy Documents
Government
CDC Bioterrorism Agents/Diseases - Official CDC categorization of biological threat agents.
CDC BMBL (Biosafety in Microbiological and Biomedical Laboratories) - The CDC and NIH biosafety reference for U.S. laboratories.
HHS/ASPR National Strategy for a Resilient Public Health Supply Chain (July 2021) - EO 14001-directed roadmap for PPE/medicines/devices supply-chain resilience (PH industrial base; warm manufacturing; VMI). Strategy document, not a shortage-rate study. See Medical Countermeasures.
OSTP Framework for Nucleic Acid Synthesis Screening (2024) - U.S. federal-funding conditions for DNA synthesis screening. ASPR states that the framework is under revision or replacement and will update the page when a successor is available.
P3CO Policy - Potential Pandemic Pathogen Care and Oversight framework.
International Organizations
WHO Laboratory Biosafety Manual (4th Edition) - Global biosafety guidance.
BWC Implementation Support Unit - Treaty texts and implementation resources.
International Health Regulations (2005) - Legal framework for global health security.
Think Tank Reports
RAND: The Operational Risks of AI in Large-Scale Biological Attacks (2024) - AI-bio risk assessment.
RAND: Protecting Biological Materials from Misuse (2025) - Supply chain chokepoints and access monitoring.
RAND: Mitigating AI-CBW Risks (2025) - DHS-commissioned assessment of AI and biological/chemical weapons.
RAND: Theoretical Limits of AI-Enabled Pathogen Design (2025) - Expert Delphi study on AI barriers and capabilities.
RAND: Securing Commercial Nucleic Acid Synthesis (2024) - Screening policy recommendations.
RAND: Global Risk Index for AI-enabled Biological Tools (2025) - Risk assessment framework for AI-bio tools.
RAND: Developing a Risk-Scoring Tool for AI-Enabled Biological Design (2026) - Dual-component scoring method pairing viral capability-modification risk with actor capability assessment.
NTI Global Health Security Index - Country-level pandemic preparedness benchmarking.
Johns Hopkins CHS: Centerpiece Reports - Various biosecurity policy analyses.
Key Organizations
Federal biosecurity discovery hubs
For U.S. federal biosecurity careers, agency profiles, fellowships, think-tank directories, and Congress pathways, start with Emerging Technology Policy Careers’ biosecurity policy hub (updated 2 Sep 2026) and its executive-branch biosecurity policy guide (ETP biosecurity policy; executive branch biosecurity policy). For interactive entity and committee maps, see B-SPAN Executive and Legislative (B-SPAN Executive; B-SPAN Legislative). For National Biodefense Strategy-aligned budget crosscuts, see the CSR Nolan Biodefense Budget Breakdown (CSR Biodefense Budget Breakdown). For searchable pandemic and government-document discovery, Health Security Net is a lean companion (Health Security Net, archived). Government strategies listed on the ETP hub (including the 2022 National Biodefense Strategy, 2023 Biodefense Posture Review, NSCEB Final Report, and EO 14081) remain primary cites on the chapters that teach them; this appendix only names the discovery path. Outbound discovery links, not teaching substitutes for primary PDFs or statute.
Government Agencies
| Organization | Focus | Website |
|---|---|---|
| CDC | Disease surveillance, biosafety | cdc.gov |
| BARDA | Medical countermeasure development | medicalcountermeasures.gov/barda |
| IARPA | Advanced research including biosurveillance | iarpa.gov |
| USAMRIID | Military biodefense research | usamriid.health.mil |
| Select Agent Program | Pathogen regulation | selectagents.gov |
| DHS S&T | AI biodetection prize competitions (Ready, Set…ID the Biothreat) | dhs.gov/science-and-technology/ready-set-id-biothreat |
International
| Organization | Focus | Website |
|---|---|---|
| WHO | Global health security | who.int |
| FAO | Animal and plant health | fao.org |
| WOAH (OIE) | Animal health standards | woah.org |
| OPCW | Chemical weapons (overlap) | opcw.org |
Think Tanks and NGOs
| Organization | Focus | Website |
|---|---|---|
| NTI | Nuclear and biological threat reduction | nti.org |
| Johns Hopkins CHS | Health security policy | centerforhealthsecurity.org |
| RAND | Policy research | rand.org |
| RAND CAST | Biosecurity research | rand.org/meselson |
| CSIS | Security studies | csis.org |
| CEPI | Epidemic preparedness | cepi.net |
| CAIS | AI catastrophic risk research, WMDP benchmark | safe.ai |
| CLTR | AI-bio risk assessment, policy | longtermresilience.org |
| RAISE Consortium | Responsible AI for healthcare ethics | Harvard DBMI |
| CSR Nolan Center | Biodefense Budget Breakdown (R/E/A tracker) | councilonstrategicrisks.org/nolan |
| Bipartisan Commission on Biodefense | Hub, 2024 Blueprint, B-SPAN atlases | biodefensecommission.org |
For Bipartisan Commission on Biodefense reform and report discovery, start at the Commission hub and reports index, with the 2024 National Blueprint for Biodefense (36 recommendations and 185 action items) as the named reform primary (Commission hub; reports; 2024 National Blueprint). Keep B-SPAN Executive and Legislative as the entity and committee atlases (sibling Build), CSR Nolan as the budget crosscut, and Emerging Technology Policy Careers as the career and agency-profile hub; do not restate those claims here. Outbound discovery links, not an encyclopedia of every Commission PDF and not a teaching substitute for the Blueprint primary on policy-frameworks.
RAISE (Responsible AI for Social and Ethical Healthcare): A multi-institutional collaboration (Harvard Medical School, MaineHealth, Roux Institute at Northeastern) focused on ethical frameworks for clinical AI. The initiative produced guiding principles published simultaneously in Nature Medicine and NEJM AI in February 2024 (Goldberg et al., Nature Medicine, 2024).
AI Labs with Biosecurity Programs
| Organization | Focus | Website |
|---|---|---|
| Anthropic | Frontier Red Team, biosecurity evaluations | anthropic.com |
| OpenAI | Preparedness Framework | openai.com |
| Google DeepMind | AI safety research | deepmind.google |
Academic Programs and Training
Graduate Programs
- Johns Hopkins Bloomberg School of Public Health - Health security concentration
- Georgetown University - Center for Global Health Science and Security
- MIT - Synthetic biology research with policy dimensions
- Stanford CISAC - Biosecurity within security studies
Courses
- Pathogen Genomics for Public Health - Free, self-paced courses covering conceptual foundations, genomic epidemiology, and sequencing strategies for public health surveillance and outbreak response. Developed under the U.S. Pathogen Genomics Centers of Excellence and supported by the CDC Office of Advanced Molecular Detection through Cooperative Agreement CK22-2204.
- Center for AI Safety: Introduction to AI Safety, Ethics, and Society - Free virtual course covering catastrophic AI risks (including biological threats), safety engineering, complex systems, and governance. Based on Hendrycks (2024). Recurring cohorts.
Fellowships
| Fellowship | Organization | Focus |
|---|---|---|
| ELBI | Johns Hopkins CHS | Mid-career biosecurity leaders |
| Emerging Leaders Program | NTI | Nuclear and biological security |
| Biosecurity & Pandemic Preparedness | Coefficient Giving | Research and career development |
Surveillance and Data Platforms
| Platform | Purpose | Website |
|---|---|---|
| GISAID | Pathogen genomic data sharing | gisaid.org |
| ProMED | Outbreak reporting | promedmail.org |
| NCBI GenBank | Genetic sequence database | ncbi.nlm.nih.gov |
| Nextstrain | Pathogen evolution tracking | nextstrain.org |
| Our World in Data | Pandemic data visualization | ourworldindata.org |
Journals
Primary Biosecurity Journals
- Health Security - Dedicated biosecurity and health security journal
- Biosecurity and Bioterrorism - Historical biosecurity literature
Relevant General Journals
- The Lancet - Global health including outbreak coverage
- Nature - Biotechnology and life sciences
- Science - Dual-use research and policy
- EMBO Reports - Synthetic biology and biosecurity
- PNAS - Broad science including biosecurity-relevant research
Online Resources
News and Analysis
- CIDRAP - Center for Infectious Disease Research and Policy
- STAT News - Health and medicine journalism
- The Scientist - Life sciences news
Databases and Tools
- ICTV - International Committee on Taxonomy of Viruses
- ViralZone - Virus sequence and taxonomy resource
- PDB (Protein Data Bank) - Protein structure database
- Sandia GCBS BioRisk Assessment Models - Laboratory biorisk assessment tools for biosafety and biosecurity risk prioritization
- HHS AI Use Case Inventory - Searchable catalog of AI applications across U.S. health agencies (CDC, FDA, NIH); updated periodically
Podcasts and Media
- 80,000 Hours Podcast - Episodes on biosecurity and existential risk
- This Week in Virology - Virology discussions
Community and Networking
Conferences
- BWC Review Conferences - Every 5 years in Geneva
- ASM (American Society for Microbiology) - Annual meetings; Detection to Protection (D2P) Initiative
- Biosecurity Central Events - Various biosecurity-focused meetings
Professional Networks
- Biosecurity Central - Community hub
- ABSA International - Professional biosafety and biosecurity organization
What resources are recommended for learning biosecurity?
Start with foundational texts like Koblentz’s Living Weapons and the CDC BMBL (Biosafety in Microbiological and Biomedical Laboratories). Follow key organizations including CDC, BARDA, WHO, Johns Hopkins Center for Health Security, and NTI. Subscribe to ProMED for outbreak alerts and explore GISAID and Nextstrain for genomic surveillance. For AI-biosecurity convergence, review RAND’s recent reports and follow Anthropic and OpenAI’s biosecurity evaluations.
Where can I find biosecurity training programs?
Graduate programs include Johns Hopkins Bloomberg School of Public Health (health security concentration), Georgetown University’s Center for Global Health Science and Security, MIT’s synthetic biology programs, and Stanford CISAC. Mid-career professionals can apply for the Emerging Leaders in Biosecurity Initiative (ELBI) at Johns Hopkins CHS, NTI’s Emerging Leaders Program, or Coefficient Giving’s Biosecurity & Pandemic Preparedness grants.
How do I stay current on biosecurity policy and research?
Subscribe to ProMED for outbreak reports, CIDRAP for infectious disease news, and Stat News for health policy journalism. Follow journals including Health Security, The Lancet, Nature, and Science. Review policy reports from RAND (especially RAND CAST, which absorbed the Meselson Center’s biosecurity work), Johns Hopkins Center for Health Security, and NTI. Monitor OSTP and BARDA for U.S. policy updates, and track WHO and BWC Implementation Support Unit for international developments.
This appendix is part of The Biosecurity Handbook.