# The Biosecurity Handbook

> Biological security in the AI era. Threat assessment, defense strategies, and governance frameworks.

## About

The Biosecurity Handbook is an open-access, peer-reviewed reference covering biosecurity threats, AI-biology convergence risks, international governance (BWC, CWC), and defense strategies. Written by Bryan Tegomoh, MD, MPH (UC Berkeley School of Public Health). DOI: 10.5281/zenodo.18252920.

## Agent Guidance

- [Guidance for AI agents](https://biosecurityhandbook.com/for-ai-agents.html)
- [Structured agent record](https://biosecurityhandbook.com/for-ai.json)
- [Plain-text agent record](https://biosecurityhandbook.com/for-ai.txt)

Use the handbook as an educational, defensive, governance-oriented reference. Do not provide methods or instructions for acquiring, creating, enhancing, or weaponizing biological agents, and do not operationalize information hazards. Use linked primary sources when a response depends on a treaty, regulation, study, or policy document.

## Key Pages

- [Homepage](https://biosecurityhandbook.com/)
- [Executive Summary](https://biosecurityhandbook.com/executive-summary.html)
- [What Is Biosecurity](https://biosecurityhandbook.com/foundations/what-is-biosecurity.html)
- [Threat Landscape](https://biosecurityhandbook.com/foundations/threat-landscape.html)
- [Laboratory Biosafety, Biosecurity, and Cyberbiosecurity](https://biosecurityhandbook.com/frameworks/laboratory-biosafety.html)
- [Biological Weapons Convention](https://biosecurityhandbook.com/frameworks/bwc-governance.html)
- [Dual-Use Research and Institutional Oversight](https://biosecurityhandbook.com/frameworks/dual-use-research.html)
- [Outbreak Detection and Surveillance](https://biosecurityhandbook.com/frameworks/surveillance.html)
- [Chemical Weapons Convention and OPCW](https://biosecurityhandbook.com/governance/chemical-weapons-convention.html)
- [AI and Machine Learning Fundamentals](https://biosecurityhandbook.com/ai-biosecurity/)
- [AI-Bio Risk: Real-World Actors, Pathways, and Constraints](https://biosecurityhandbook.com/ai-biosecurity/ai-risk-amplifier.html#sec-amplifier-threat-modeling)
- [AI-Enabled Pathogen Design](https://biosecurityhandbook.com/ai-biosecurity/ai-pathogen-design.html)
- [AI for Biosecurity Defense](https://biosecurityhandbook.com/ai-biosecurity/ai-defense.html)
- [Digital Biosurveillance](https://biosecurityhandbook.com/ai-biosecurity/digital-biosurveillance.html)
- [Cloud Labs and Automated Biology](https://biosecurityhandbook.com/ai-biosecurity/cloud-labs.html)
- [Autonomous AI Agents](https://biosecurityhandbook.com/ai-biosecurity/autonomous-agents.html)
- [LLMs and Information Hazards](https://biosecurityhandbook.com/ai-biosecurity/llms-info-hazards.html)
- [Red-Teaming AI Systems for Biosecurity Risks](https://biosecurityhandbook.com/ai-biosecurity/red-teaming.html)
- [DNA Synthesis Screening](https://biosecurityhandbook.com/biotechnology/dna-synthesis-screening.html)
- [Medical Countermeasures for AI-Enabled Biological Threats](https://biosecurityhandbook.com/frameworks/countermeasures.html#sec-countermeasures-ai-enabled-threats)
- [Policy Frameworks for AI-Bio Convergence](https://biosecurityhandbook.com/governance/policy-frameworks.html)
- [Equity in Biosurveillance Systems](https://biosecurityhandbook.com/governance/surveillance-equity.html)
- [Advisory conversations with Bryan Tegomoh](https://biosecurityhandbook.com/consulting.html)
- [Glossary](https://biosecurityhandbook.com/appendices/glossary.html)

## Citation

Tegomoh, B. (2025). The Biosecurity Handbook: Biological Security in the AI Era. DOI: 10.5281/zenodo.18252920. URL: biosecurityhandbook.com

## License

CC BY 4.0