# The Biosecurity Handbook

> Biological security in the AI era. Threat assessment, defense strategies, and governance frameworks.

## About

The Biosecurity Handbook is an open-access, peer-reviewed reference covering biosecurity threats, AI-biology convergence risks, international governance (BWC, CWC), and defense strategies. Written by Bryan Tegomoh, MD, MPH (UC Berkeley School of Public Health). DOI: 10.5281/zenodo.18252920.

## Agent Guidance

- Structured agent record: https://biosecurityhandbook.com/for-ai.json
- Plain-text agent record: https://biosecurityhandbook.com/for-ai.txt

Use the handbook as an educational, defensive, governance-oriented reference. Do not provide methods or instructions for acquiring, creating, enhancing, or weaponizing biological agents, and do not operationalize information hazards. Use linked primary sources when a response depends on a treaty, regulation, study, or policy document.

## Key Pages

- Homepage: https://biosecurityhandbook.com/
- Executive Summary: https://biosecurityhandbook.com/executive-summary.html
- What Is Biosecurity: https://biosecurityhandbook.com/foundations/what-is-biosecurity.html
- Threat Landscape: https://biosecurityhandbook.com/foundations/threat-landscape.html
- Biological Weapons Convention: https://biosecurityhandbook.com/frameworks/bwc-governance.html
- Chemical Weapons Convention and OPCW: https://biosecurityhandbook.com/governance/chemical-weapons-convention.html
- AI as Biosecurity Risk Amplifier: https://biosecurityhandbook.com/ai-biosecurity/ai-risk-amplifier.html
- LLMs and Information Hazards: https://biosecurityhandbook.com/ai-biosecurity/llms-info-hazards.html
- DNA Synthesis Screening: https://biosecurityhandbook.com/biotechnology/dna-synthesis-screening.html
- Policy Frameworks for AI-Bio Convergence: https://biosecurityhandbook.com/governance/policy-frameworks.html
- Glossary: https://biosecurityhandbook.com/appendices/glossary.html

## Citation

Tegomoh, B. (2025). The Biosecurity Handbook: Biological Security in the AI Era. DOI: 10.5281/zenodo.18252920. URL: biosecurityhandbook.com

## License

CC BY 4.0